543 Mucous membrane pemphigoid is associated with multiple somatic and psychiatric comorbidities

Mucous membrane pemphigoid (MMP) is a group of rare autoimmune blistering conditions mostly affecting the mucous membranes elderly people. National epidemiological data and larger studies on comorbidities MMP are scarce. We analyzed incidence in retrospective, case-control registry study all patients diagnosed specialized health care hospitals between 1996 2018 Finland (n=268). Also, specialties diagnostic code registrations were determined. The mean was 0.44 per million year it varied during period. female to male ratio 1,8:1. In 90.4% (n=245) patients, diagnosis registered either dermatology or dentistry units remaining 6.7% (n=18) 1.9% (n=5) ophthalmology other specialties, respectively. analysis comorbidities, several psychiatric somatic disorders significantly associated with MMP. For example, depression anxiety more common than control group, odds ratios (OR) being 1.98 (95% confidence interval [CI]1.12-3.50) 2.26 CI 1.03-4.96), Of multiple associating rheumatoid arthritis four times, epilepsy (as only neurological comorbidity) three times group. Solid malignancies not compared population. conclusion, we found be line previous detected notable burden among large national registry-based dataset.